Wound dressing based collagen biomaterials containing usnic acid as quorum sensing inhibitor agent: synthesis, characterization and bioevaluation.

Overview

Alexandru Mihai Grumezescu, Ecaterina Andronescu, Madalina Georgiana Albu, Anton Ficai, Denisa Dragu: Wound dressing based collagen biomaterials containing usnic acid as quorum sensing inhibitor agent: synthesis, characterization and bioevaluation. Current Organic Chemistry, 17(2):125-131, 2013.

ABSTRACT

The aims of this research were to obtain improved wound dressings based on collagen (COLL), polysaccharides (dextran=DEX, diethylaminoethyl-cellulose= DEAEC), silica network and usnic acid, as quorum sensing inhibitor. FT-IR, SEM, interaction with eukaryotic cells and a novel protocol to evaluate the antimicrobial activity of the new wound dressing, firstly reported in literature were used for the characterization of fabricated wound dressings. The obtained wound dressings are not cytotoxic, do not influences the mesenchymal stem and exhibit good anti-biofilm properties. Taken together, these results are suggesting that the new systems can be safely used for local applications on the lesional tissues.

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