Water soluble magnetite nanoparticles for antimicrobial drugs delivery.


Dan Eduard Mihaiescu, Mariana Horja, Irina Gheorghe, Anton Ficai, Alexandru Mihai Grumezescu, Coralia Bleotu, Carmen Mariana Chifiriuc: Water soluble magnetite nanoparticles for antimicrobial drugs delivery. Letters in Applied NanoBioScience, 1(2):45-49, 2012.


Water-soluble magnetite has been prepared through precipitation approach. These nanoparticles coated with sulfanilic acid could be dispersed in hydrated aqueous systems. The product was characterized with X-ray powder diffraction (XRD), Dynamic Light Scattering (DLS) and the in vitro efficacy as antibiotic delivery vehicles as well as their influence on the eukariotic cells. The XRD pattern confirm the product to be Fe3O4. The nanoparticles with average size 10.45 nanometers are not cytotoxic and do not influence the eukariotic HeLa cell cycle, representing potential tools for the delivery of drugs in a safe manner. Water soluble magnetite improves the activity of currently used antibiotics, representing potential as a nanocarrier for these antimicrobial substances, to achieve extracellular and intracellular targets.