Alexandru Mihai Grumezescu*, Ecaterina Andronescu, Anton Ficai, Denisa Ficai, Keng Shiang Huang, Irina Gheorghe, Mariana Carmen Chifiriuc: Water Soluble magnetic biocomposite with potential applications for the antimicrobial therapy. Biointerface Research in Applied Chemistry, 2(6):469-475, 2012.
The objective of this work was to synthesize a water soluble carrier comprised of magnetite coated with chitosan for active delivery of antibiotics. The biocomposite was characterized by FT-IR, XRD and SEM. The water soluble carrier enhanced the activity of beta-lactam antibiotics (penicillins, cephalosporins) recommended for the assessment of in vitro susceptibility of Escherichia coli and Pseudomonas aeruginosa strains.