Keng-Shiang Huang, Yung-Sheng Lin, Chih-Hui Yang, Alexandru Mihai Grumezescu, Chih-Yu Wang: Synthesis of uniform core-shell gelatin-alginate microparticles as intestine-released oral delivery drug carrier, Electrophoresis, 35(2-3), 330-336, 2014.
A core-shell gelatin-alginate composite used for intestine-released oral delivery drug carrier was synthesized through microfluidic technique. At the fixed continuous phase flow rate, the size of the core-shell gelatin-alginate microparticles increases with the dispersed phase flow rate, and monodispersity can be retained (the variation coefficient for the diameter distribution can be kept less than 10%). The fabricated microparticles could remain intact in gastric juice for at least 3 h, indicating that the gelatin core could be well protected by alginate shell in acid environment. However, the alginate shell of the microparticles would swell or collapse in alkali environment in half an hour, assuring the controlled drug release in intestinal juice. The fabricated uniform core-shell gelatin-alginate microparticles were potential as pH-responsive drug carriers.