Ion Anghel, Valentina Grumezescu, Ecaterina Andronescu, Georgiana Alina Anghel, Alexandru Mihai Grumezescu*, Dan Eduard Mihaiescu, Mariana Carmen Chifiriuc: Protective effect of magnetite nanoparticle/Salvia officinalis essential oil hybrid nanobiosystem against fungal colonization on the Provox® voice section prosthesis. Digest Journal of Nanomaterials and Biostructures, 7(3):1205-1212,2012.
This study is aimed to evaluate a novel nanobisystem based on magnetic nanofluid and Salvia officinalis essential oil for coating the Provox voice section prostheses surfaces with desired antibiofilm properties. The essential oil microwave assisted extraction was performed in a Neo-Clevenger type apparatus and its chemical composition was settled by GC-MS analysis. Fe3O4/C18 solubilized in chloroform and oriented in magnetic field was used for coating of the catheter sections of 1 cm. The extra-shell (essential oil) was applied by adsorption in a secondary covering treatment. The fungal biofilm architecture was assessed by confocal laser scanning microscopy (CLSM). The new Fe3O4/C18/essential oil nanobiosystem exhibited a fungicidal effect and inhibited the fungal adherence, representing thus, an interesting option for the medical field, opening new directions for the design of modified surfaces with desired and controlled antibiofilm properties.