Novel strategies to eradicate bacterial communities based on nano and biomaterials.


Alexandru Mihai Grumezescu*: Novel strategies to eradicate bacterial communities based on nano and biomaterials, Current Organic Chemistry, 18, 151, 2014.


Infectious diseases continue to be one of the greatest health challenges worldwide. The main drawbacks for the currently used antimicrobial agents are the development of multiple drug resistance and adverse side effects to conventional antibiotics. Drug resistance enforces high dose administration of therapeutic agents, often generating intolerable toxicity. There is now widespread recognition of the biofilms contribution to human infection. Cases of biofilm infection include the well-known examples of device-related infections such as those associated with artificial joints, prosthetic heart valves and catheters. Nanotechnology, the use of materials with dimensions on the atomic or molecular scale offers new perspectives for the development of new approaches to destroy or inhibit the activity of different microbial strains, as well as for obtaining optimized biomaterials with anti-adherence properties. The explosion of nanotechnology applications in the biomedical field motivates the purpose of this special issue of Current Organic Chemistry to summarize current research findings concerning the nanotechnology based solutions emerged as new tools to track the current challenges in treating infectious diseases. Chifiriuc et al.,…