Alexandru Mihai Grumezescu, Ecaterina Andronescu, Georgeta Voicu, Keng-Shiang Huang, Chih-Hui Yang, Anton Ficai, Bogdan StefanVasile, Valentina Grumezescu, Coralia Bleotu, Mariana Carmen Chifiriuc: New silica nanostructure for the improved delivery of topical antibiotics used in the treatment of staphylococcal cutaneous infections. International Journal of Pharmaceutics, 463, 170-176, 2013.
In this paper, we report the synthesis, characterization (FT-IR, XRD, BET, HR-TEM) and bioevaluation ofa novel -aminobutiric acid/silica (noted GABA-SiO2or -SiO2) hybrid nanostructure, for the improvedrelease of topical antibiotics, used in the treatment of Staphylococcus aureus infections. GABA-SiO2showedIR bands which were assigned to Si–O–Si (stretch mode). The XRD pattern showed a broad peak in therange of 18–30◦(2), indicating an amorphous structure. Based on the BET analysis, estimations aboutsurface area (438.14 m2/g) and pore diameters (4.76 nm) were done. TEM observation reveals that theprepared structure presented homogeneity and an average size of particles not exceeding 10 nm. Theprepared nanostructure has significantly improved the anti-staphylococcal activity of bacitracin andkanamycin sulfate, as demonstrated by the drastic decrease of the minimal inhibitory concentration ofthe respective antibiotics loaded in the GABA-SiO2nanostructure. These results, correlated with the highbiocompatibility of this porous structure, are highlighting the possibility of using this carrier for thelocal delivery of the antimicrobial substances in lower active doses, thus reducing their cytotoxicity andside-effects.