Alexandru Mihai Grumezescu*, Alina Holban, Ecaterina Andronescu, Anton Ficai, Coralia Bleotu, Mariana Carmen Chifiriuc: Microbiological applications of a new water dispersible magnetic nanobiocomposite. Letters in Applied NanoBioScience, 1(4):83-90, 2012.
Our goal was to fabricate a novel water dispersible nanobiocomposite useful for the improvement of classical antimicrobial therapies. Water-soluble magnetite nanoparticles were protected by chitosan and polyvinyl alcohol to increase system’s bioaccommodation. The presence of magnetite was confirmed by XRD. SEM results also indicate that the fabricated nanobiocomposite is composed of nanosized magnetite particles. FT-IR spectrum of the nanobiocomposite, revealed the presence of adsorption peaks specific for PVA, CS and Fe3O4. Our results demonstrate that the nanobiocomposite has the ability to modify and improve antimicrobial activity of gentamicin, ciprofloxacin and cefotaxime against S.aureus and P.aeruginosa. Fabricated nanobiocomposite exhibited a low cytotoxic effect on eukaryotic cells being thus a good candidate for developing new antimicrobial strategies aiming to potentate the antimicrobial effect of drugs and controlling their delivery.