Alina Maria Holban, Alexandru Mihai Grumezescu, Ecaterina Andronescu, Valentina Grumezescu, Carmen Mariana Chifiriuc, Radu Radulescu: Magnetite-usnic acid nanostructured bioactive material with antimicrobial activity. Romanian Journal of Materials, 43, 402-407, 2013.
With the great increasing of antibiotic resistance, novel therapeutic approaches aiming to reduce resistance and bacterial tolerance to antibiotics are currently developing. Nanotechnology seems an fficient approach in dealing with resistant infections. One of the most challenging idea is to produce materials and surfaces exhibiting high antimicrobial effects but also a good biocompatibility with human cells. In this paper, we report a newly fabricated biocompatible, resorbable bioactive wound dressing based polyvinyl alcohol and usnic acid functionalized magnetite nanoparticles (Fe3O4@UA). This material revealed a good anti-staphylococcal activity, mainly due to the bio-active natural usnic acid (UA) compound entrapped into Fe3O4@UA. This wound dressing produces an efficient and prolonged release of the bio-active compound. Furthermore, its absorbent structure recommends this material as a good candidate for treating infected wounds.