Dan Eduard Mihaiescu, Alexandru Mihai Grumezescu, Paul Catalin Balaure, Diana Elena Mogosanu, Vanessa Traistaru: Magnetic scaffold for drug targeting: evaluation of cephalosporins controlled release profile. Biointerface Research in Applied Chemistry, 1(5):191-195, 2011.
The great problem associated with drug administration is the inability to target a specific area of the body. To reach an acceptable therapeutic level, large doses of the drug must be administered. Only a part of the dose will actually reach the intended disease. Magnetic targeting simplifies drug administration procedures, increases the concentration of the drug at target sites and decreases the concentration of the drug at non-target sites. This study was focused to evaluate the controlled release profile of cephalosporins from magnetic diethylaminoethyl-cellulose hybrid material (magnetic scaffold). Dissolution behavior of these magnetic scaffolds was evaluated using a modified HPLC system. It was found that in all cases, at large time values, the cephalosporin’s concentration was much below the solubility plateau for the pure active compound, demonstrating that the adsorption on the surface of magnetic scaffolds is a valuable procedure to attain controlled release.