In vitro assay of the antimicrobial activity of Fe3O4 and CoFe2O4 / oleic acid – core/shell on clinical isolates of bacterial and fungal strains.

Overview

Alexandru Mihai Grumezescu*, Dan Eduard Mihaiescu, Diana Elena Mogoşanu, Mariana Carmen Chifiriuc, Veronica Lazǎr, Ioana Cǎlugǎrescu, Vanessa Trǎistaru: In vitro assay of the antimicrobial activity of Fe3O4 and CoFe2O4 / oleic acid – core/shell on clinical isolates of bacterial and fungal strains. Optoelectronics and Advanced Materials-Rapid Communication, 4(11):1798–1801, 2010.

ABSTRACT

The aim of the present study was to evaluate the antimicrobial activity of Fe3O4 and CoFe2O4 / oleic acid – core microwave conditions. The dimensions of Fe3O4 and CoFe2O4 nanoparticles did not exceed the 20 nm range and they were characterized by High Resolution Transmision Electron Microscopy. The nanoparticles were screened for their in vitro antimicrobial activity against Gram – positive (Staphylococcus aureus, Enterococcus faecalis), Gram–negative bacteria (Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa) and fungal strains (Candida albicans), using both reference and clinical, multidrug resistant strains. The quantitative assay of the antimicrobial activity was performed by both microdilution method in 96-well microplates in order to establish the minimal inhibitory concentration (MIC).

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