Carmen Mariana Chifiriuc, Alexandru Mihai Grumezescu*, Crina Saviuc, Cristina Croitoru, Dan Eduard Mihaiescu, Veronica Lazar: Improved antibacterial activity of cephalosporins loaded in magnetic chitosan microspheres. International Journal of Pharmaceutics, 436(1–2): 201-205, 2012.
During the present study, we have evaluated magnetic chitosan as a potential drug delivery device, by specifically determining if chitosan could elute antibiotics in an active form that would be efficacious
in inhibiting Staphylococcus aureus and Escherichia coli growth. We have demonstrated that the incorporation of cephalosporins of second, third and fourth generation into magnetic chitosan microspheres
can possibly lead to an improved delivery of antibiotics in active forms, probably due to the inherent properties of chitosan.