Ion Anghel, Alexandru Mihai Grumezescu, Alina Maria Holban, Irina Gheorghe, Mihaela Vlad, Georgiana Alina Anghel, Paul Catalin Balaure, Carmen Mariana Chifiriuc, Ioana Mihaiela Ciuca: Improved activity of aminoglycosides entrapped in silica networks against microbial strains isolated from otolaryngological infections. Farmacia, 62, 69-78, 2014.
The purpose of this study was to investigate the efficiency of natural and synthetic zeolites as carriers for aminoglycoside antibiotics,by using an adapted diffusion method and microbial strains isolated from otolaryngological infections. The results showed that the natural and synthetic zeolites proved to be excellent carriers for aminoglycosides, exhibiting a strong potentiator effect on the activity of kanamycin and streptomycin, especially against the Gram-positive bacterial strains, as demonstrated by the drastic increase of the growth inhibition zone diameters induced by the antibiotics entrapped in the silica networks. These results are demonstrating the utility of silica networks in the pharmaceutical industry for the identification of new ways to improve the bioavailability and dissolution of the currently used antibiotics.