Hybrid nanostructurated material for biomedical applications.


 Crina Saviuc, Alexandru Mihai Grumezescu, Alina Holban, Carmen Chifiriuc, Dan Mihaiescu, Veronica Lazar: Hybrid nanostructurated material for biomedical applications. Biointerface Research in Applied Chemistry, 1(2):64, 2011.


The purpose of this study was to assess the antibacterial activity of a novel hybrid organic-inorganic nanostructurated material based on Fe3O4/PEG600/Citrus maxima essential oil. The core/shell material was synthesized by reacting PEG600 with Fe3O4 nanoparticles, under microwave condition. The core/shell was modified by adsorbtion of C. maxima essential oil as an extra-shell. The nanostructurated material was characterized by HR-TEM and FT-IR. The hybrid nanomaterial was screened for their in vitro antimicrobial activity against Gram – positive and Gram–negative bacterial strains. The in vitro assay of the influence of the magnetic biomaterial on bacterial adherence to cellular and acellular substrata and biofilm development demonstrated that novel hybrid nanostructurated materials could be used for the development of novel antimicrobial materials with anti-adherent properties.