Hybrid materials for drug delivery of rifampicin: evaluation of release profile.


Alexandru Mihai Grumezescu, Dan Eduard Mihaiescu, Dragoş Tamaş: Hybrid materials for drug delivery of  rifampicin: evaluation of release profile. Biointerface Research in Applied Chemistry, 1(6):229-235, 2011.


The aim of the present investigation was to evaluate the dissolution profile of rifampicin, to study the design parameters of magnetic scaffolds and to evaluate the in vitro release characteristics. A series of magnetic hybrid materials were developed with different release rates using chitosan (Ch) and diethylaminoethyl-cellulose (DeaeC). The duration of rifampicin release could be tailored by varying the polymer type. Rifampicin was found to follow a linear release profile with time from all magnetic polysaccharide scaffolds. Using suitable polysaccharide scaffolds and proper optimization of the processing techniques, it was possible to design the controlled release formulations of rifampicin that could provide the sufficient initial release and release extension up to 24 h for the drug despite of the wide variations in their physicochemical properties.