Alexandru Mihai Grumezescu, Ecaterina Andronescu, Anton Ficai, Georgeta Voicu, Octavian Cocos, Mariana Carmen Chifiriuc: Eugenia cayophyllata essential oil-SiO2 biohybrid structure for the potentiation of antibiotics activity. Romanian Journal of Materials, 43(2):160-166, 2013.
The aim of this paper was to obtain a hybrid biostructure, combining the Eugenia carryophyllata essential oil and a silica network and to demonstrate by in vitro studies its potential chemotherapeutic value to improve the efficacy of different classes of antibiotics currently used against Gram-positive and Gram-negative bacterial strains. The obtained hybrid structure significantly improved the activity of topic antibiotics, such as bacitracin and neomycin sulfate, by significantly decreasing their minimal inhibitory concentration. This antibiotics potentiating activity, together with no measurable in vitro cytotoxicity, make this hybrid structure potentially relevant for biomedicine applications, especially in the antimicrobial therapy.