Carboxymethyl-cellulose/Fe3O4 nanostructures for antimicrobial substances delivery.


Vlad Mihaela, Ecaterina Andronescu, Alexandru Mihai Grumezescu*, Anton Ficai, Georgeta Voicu, Coralia Bleotu, Mariana Carmen Chifiriuc: Carboxymethyl-cellulose/Fe3O4  nanostructures for antimicrobial substances delivery. Bio-Medical Materials and Engineering – An International Journal, accepted, 2013.


The synthesis of carboxymethyl-cellulose/magnetite (CMC/Fe3O4) was carried out. This magnetic hybrid material was characterized by infrared spectroscopy, scanning electron microscopy and X-ray diffractometry. The adsorption of norfloxacin and cefotaxim antimicrobial substances (ATB) onto the CMC/Fe3O4 was performed in order to investigate the capacity of the magnetic scaffold to improve the antimicrobial activity of the respective therapeutic agents, assessed by an in vitro quantitative assay. The obtained results proved that CMC/Fe3O4/ATBs might be a promising candidate for the development of efficient and cheap antimicrobial drugs carriers under magnetic field.