Caprolactam-silica network, a strong potentiator of the antimicrobial activity of kanamycin against Gram-positive and Gram-negative bacterial strains.

Overview

Georgeta Voicu, Valentina Grumezescu, Ecaterina Andronescu, Alexandru Mihai Grumezescu*, Anton Ficai, Cristina Daniela Ghitulica, Irina Gheorghe, Mariana Carmen Chifiriuc: Caprolactam-silica network, a strong potentiator of the antimicrobial activity of kanamycin against Gram-positive and Gram-negative bacterial strains. International Journal of Pharmaceutics, 446:63–69, 2013.

ABSTRACT

Here, we report the fabrication of a novel -caprolactam-silica (-SiO2) network and assessed its biocompatibility and ability to improve the antimicrobial activity of kanamycin. The results of the quantitative
antimicrobial assay demonstrate that the obtained -SiO2 network has efficiently improved the kanamycin activity on Staphylococcus aureus ATCC 25923 and Escherichia coli ATCC 25922 strains, with a significant decrease of the minimum inhibitory concentration. The -SiO2 network could be feasibly obtained and represents an alternative for the design of new antibiotic drug carriers or delivery systems to control bacterial infections.

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