Antimicrobial and biocompatibility assay of newly fabricated materials based copper or zinc alginate and SiO2 network.

Overview

Valentina Grumezescu, Carmen Mariana Chifiriuc, Alina Maria Holban, Petruta Stoica, Alexandru Mihai Grumezescu, Georgeta Voicu, Gabriel Socol, Keng Shiang Huang, Coralia Bleotu, Radu Radulescu: Antimicrobial and biocompatibility assay of newly fabricated materials based copper or zinc alginate and SiOnetwork. Digest Journal of Nanomaterials and Biostructures, 8(2):869-876, 2013.

ABSTRACT

Here we report the synthesis and bio-evaluation of a newly crosslinked Cooper and Zinc Alginate with/without SiO2 network exhibiting significant antimicrobial activity against Enterococcus faecalis, in significantly lower concentrations than the plain Copper or Zinc solutions (p<0.05). Furthermore, the obtained hybrid materials did not exhibit any cytotoxic effect against eukaryotic cells, proving their good biocompatibility and enabling them to be used as drug delivery systems and scaffolds for tissue engineering, providing prolonged, effective antimicrobial activity.

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