Ion Anghel, Alexandru Mihai Grumezescu, Alina Georgiana Anghel, Iulian Chirea, Luminita Marutescu, Dan Eduard Mihaiescu, Mariana Carmen Chifiriuc: Antibiotic potentiator effect of the natural and synthetic zeolites with well defined nanopores with possible ENT clinical applications. Farmacia, 60(5):688-695,2012.
An adapted difussimetric method was used in order to assess the potentiator effect of some natural (NZ) and synthetic zeolites (SZ)with well defined nanopores on the antibiotic (ATB) susceptibility of Enterococcus fecalis, Pseudomonas aeruginosa, Staphylococcus aureus, Bacillus subtilis and Escherichia coli strains to some of the currently used antibiotics, i.e. neomycin, polymixin, norfloxacin and cefotaxime. Our results show that the natural and synthetic zeolites with well defined nanopores release antibiotics with different chemical structures in an active form and improve their antimicrobial effect against Gram-positive and Gram-negative bacterial strains, constituting promissing delivery systems for various classes of commonly used antibiotics.